A comprehensive analysis of the potential biological functions and prognostic values of SREBF1 for multiple cancer types including colorectal cancer

Abstract

AbstractAs an important molecule involved in lipid metabolism, Sterol Regulatory Element-Binding Protein 1 (SREBF1) plays a critical role in governing cellular lipid synthesis and uptake. However, a comprehensive understanding of the biological significance of SREBF1 in pan-cancer remains elusive. In this study, we aimed to comprehensively analyze the functional characteristics of SREBF1 in human cancers, including colorectal cancer (CRC). Our study utilized various databases and tools such as TCGA, GEO, TIMER2.0, GEPIA2.0, UALCAN, and the Human Protein Atlas to examine SREBF1 expression, genetic alterations, immune infiltration, single-cell sequencing, survival analysis, and gene enrichment. The results revealed that the expression of SREBF1 exhibited significant variations across different cancer types, and was closely associated with patient prognosis and immune infiltration. Moreover, the gene function assays indicated SREBF1 significantly affect cell growth and migration. Overall, the findings suggest that SREBF1 could serve as a potential prognostic biomarker and a novel therapeutic target in different cancer types.