Abstract
AbstractTemperament can be defined as the emotional variability among animals of the same species in response to the same stimulus, thus being able to group animals by reactivity as nervous, intermediate or calm. The main objective for this study was to identify genomic regions with the temperament phenotype measured by the Isolation Box Test (IBT) by single-step genome wide association studies (ssGWAS). The database used consisted of 4,317 animals with temperament records, and 1,697 genotyped animals with 38,268 effective SNP after quality control. We identified three genomic regions that explained the greatest percentage of the genetic variance, resulting in 25 SNP associated with candidate genes on chromosomes 6, 10 and 21. A total of nine candidate genes are reported for the temperament trait, which are:PYGM,SYVN1,CAPN1,FADS1,SYT7,GRID2,GPRIN3,EEF1A1andFRY, linked to energetic activity of the organism, synaptic transmission, meat tenderness and calcium associated activities. This is the first study to identify these genetic variants associated with temperament in sheep, leading the opportinuty to potential applications of these molecular markers in future behavioral research.
Publisher
Cold Spring Harbor Laboratory
Reference102 articles.
1. Hot topic: A unified approach to utilize phenotypic, full pedigree, and genomic information for genetic evaluation of Holstein final score
2. Aguilar, I. , Misztal, I. , Tsuruta, S. , Legarra, A. , Wang, H. , Legarra, A ., 2020. PREGSF90 – POSTGSF90: Computational Tools for the Implementation of Single-step Genomic Selection and Genome-wide Association with Ungenotyped Individuals in BLUPF90 Programs. 10th World Congress on Genetics Applied to Livestock Production (WCGALP), Aug 2014, Vancouver, Canadá. American Society of Animal Sciense. Proceedings. https://hal.inrae.fr/hal-02743809
3. A Systematic Review of Genomic Regions and Candidate Genes Underlying Behavioral Traits in Farmed Mammals and Their Link with Human Disorders
4. Genome-wide association and multi-omic analyses reveal ACTN2 as a gene linked to heart failure
5. Role of phosphorylation on characteristics of glycogen phosphorylase in lamb with different glycolytic rates post-mortem