Abstract
AbstractProstate cancer (PCa) continues to trend among top 3 cancers that kill men over 20 years in the United Kingdom and worldwide despite extensive research and resources directed towards its treatment and prevention. In the application of a hallmark of survival mechanisms by the cancer, our study used mRNA seq data to identify genes that are increasingly mutated with progressing PCa from a cohort of 491 PCa patients. We found thatENOX1, CCDC122andLACC1deep deletion was positively associated with increasing age of diagnosis. Pathway analysis of enriched genes, following their deep deletion identified estrogen biosynthesis, KSRP signalling, omega 3 and 6 fatty acid biosynthesis and, Rap1 signalling as the top 5 enriched pathways. Previous individual and combined role of these genes in PCa progression was not fully established but thanks to this study, these pathways could be druggable targets in PCa patients with these gene deep deletions.
Publisher
Cold Spring Harbor Laboratory
Reference54 articles.
1. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries
2. Chhikara, B. S. & Parang, K. Global Cancer Statistics 2022: the trends projection analysis. Chem. Biol. Lett. 10, Vol. 10 No. 1 (2023) (2023).
3. Prostate cancer incidence statistics | Cancer Research UK. https://www.cancerresearchuk.org/health-professional/cancer-statistics/statistics-by-cancer-type/prostate-cancer/incidence#heading-Three (2023).
4. Brain Metastases from Prostate Cancer: An 11-Year Analysis in the MRI Era with Emphasis on Imaging Characteristics, Incidence, and Prognosis;J. Neuroimaging,2014
5. Risk of Pathologic Upgrading or Locally Advanced Disease in Early Prostate Cancer Patients Based on Biopsy Gleason Score and PSA: A Population-Based Study of Modern Patients