Aβ-affine bifunctional copper chelators capable of Aβ-induced oxidative stress reduction and amyloid disaggregation-Reference-Cited by-同舟云学术

Aβ-affine bifunctional copper chelators capable of Aβ-induced oxidative stress reduction and amyloid disaggregation

Published:2023-10-13 Issue: Volume: Page:
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Author:

Krasnovskaya Olga,Abramchuk Daniil,Vaneev Alexander,Gorelkin Peter,Abakumov Maxim,Timoshenko Roman,Chmelyuk Nelly,Vadekhina Veronika,Kuanaeva Regina,Dubrovin Evgeniy V.,Kolmogorov Vasilii,Beloglazkina Elena,Erofeev Alexander

Abstract

Alz-5 acts as a bifunctional chelator that can interact with various Aβ aggregates and reduce their neurotoxicity. Single-cell ROS measurements provided by Pt-nanoelectrode technique revealed a significant antioxidant properties of Alz-5 in Aβ42- affected SH-SY5Y cell. AFM data obtained on Aβ42fibrils clearly indicate an anti-aggregating property of Alz-5. Young’s modulus mapping on living SH-SY5Y cells revealed an ability of Alz-5 to decrease cell rigidity in Aβ42- affected SH-SY5Y cells.

Publisher

Cold Spring Harbor Laboratory

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