Author:
Timonina Daria,Hormazabal Genesis V,Heckenbach Indra,Anderton Edward,Haky Lauren,Floro Ariel,Riley Rebeccah,Kwok Ryan,Breslin Stella,Ingle Harris,Tiwari Ritesh,Bielska Olga,Scheibye-Knudsen Morten,Kasler Herbert,Campisi Judith,Walter Marius,Verdin Eric
Abstract
AbstractThe role of sleep in systemic aging remains poorly understood, despite sleep’s essential function in preserving overall health and the prevalence of reduced sleep quality in modern society. Although reduced sleep correlates with an elevated risk of age-related diseases in humans, the mechanisms underlying this are unclear. In this study, we established a link between sleep and aging by demonstrating that disrupting sleep in C57BL/6 mice drives cellular senescence in the visceral adipose tissue. Sleep disruption also led to increased oxidative stress and DNA damage, both recognized triggers for senescence induction. Cellular senescence is implicated in numerous age-related conditions which are associated with insufficient sleep, such as cardiovascular disease, type 2 diabetes, and chronic inflammation. Our findings identify an accumulation of senescent cells in the adipose tissue, which serves as a potential target through which disturbed sleep accelerates the aging process and elevates the risk of age-related diseases.
Publisher
Cold Spring Harbor Laboratory
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