Abstract
AbstractThe discovery of WzA, an octomeric helical barrel integral bacterial outer membrane protein, has challenged the widely held understanding that all integral outer membrane proteins of gram-negative bacteria are closed β-barrels composed of transmembrane β-strands. WzA is a member of the outer membrane polysaccharide exporter family and a bioinformatics analysis suggests that other members of the family may also contain outer membrane transmembrane segments that are helical. A review of the literature indicates that in addition to Wza, outer membrane core complex proteins of the type IV secretion systems also contain transmembrane segments that are helical.
Publisher
Cold Spring Harbor Laboratory
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