Adult Neurogenesis Reconciles Flexibility and Stability of Olfactory Perceptual Memory

Abstract

1SummaryIn brain regions featuring ongoing plasticity, the task of quickly encoding new information without overwriting old memories presents a significant challenge. In the rodent olfactory bulb, which is renowned for substantial structural plasticity driven by adult neurogenesis and persistent turnover of dendritic spines, we show that such plasticity is vital to overcoming this flexibility-stability dilemma. To do so, we develop a computational model for structural plasticity in the olfactory bulb and show that the maturation of adult-born neurons facilitates the abilities to learn quickly and forget slowly. Particularly important to achieve this goal are the transient enhancement of the plasticity, excitability, and susceptibility to apoptosis that characterizes young neurons. The model captures many experimental observations and makes a number of testable predictions. Overall, it identifies memory consolidation as an important role of adult neurogenesis in olfaction and exemplifies how the brain can maintain stable memories despite ongoing extensive plasticity.