Uncovering organizing principles of protein-protein interaction networks

Abstract

AbstractThis study explores the intricate world of protein-protein interaction (PPI) networks and the critical role of hub proteins within them. PPIs, mediated by various biomolecular forces, orchestrate diverse cellular processes through transient or stable interactions. The study delves into the unique ability of hubs to connect with numerous partners within the network. This research investigates the network properties and focuses on hub-centric questions. This study explores information-carrying capacity, power laws in protein circuits, connectivity profiles of hub proteins, and network expansion or shrinkage during evolution. The study validates the power law for connectivity, identifies a marginal network compression in evolution, unveils hub connectivity patterns, and encourages the exploration of the correlation between protein structure, connectivity, and function. These findings offer valuable insights into network design principles and the critical role of hub proteins in cellular function and evolution.