Individual trajectories for recovery of neocortical activity in disorders of consciousness

Author:

Tewarie Prejaas K.B.ORCID,Abeysuriya RomeshORCID,Panda RajanikantORCID,Nùñez Pablo,Vitello Marie M.ORCID,van der Lande GlennORCID,Gosseries OliviaORCID,Thibaut AuroreORCID,Laureys StevenORCID,Deco GustavoORCID,Annen JitkaORCID

Abstract

AbstractThe evolution from disturbed brain activity to physiological brain rhythms can precede recovery in patients with disorders of consciousness (DoC). Accordingly, intriguing questions arise: What are the pathophysiological factors responsible for disrupted brain rhythms in patients with DoC, and are there potential pathways for individual patients with DoC to return to normal brain rhythms? We addressed these questions at the individual subject level using biophysical simulations based on electroencephalography (EEG). The main findings are that unconscious patients exhibit a loss of excitatory corticothalamic synaptic strength. Synaptic plasticity in this excitatory corticothalamic circuitry fosters physiological brain rhythms in the selection of patients with DoC. The extent to which this occurred was correlated with cerebral glucose uptake. The current findings emphasize the importance of excitatory thalamocortical activity in reestablishing normal brain rhythms after brain injury and show that biophysical modelling of the corticothalamic circuitry could help select patients that might be potentially receptive to treatment and undergo plasticity.

Publisher

Cold Spring Harbor Laboratory

Reference62 articles.

1. Physiologically based arousal state estimation and dynamics;In: Journal of Neuroscience Methods,2015

2. Real-time automated EEG tracking of brain states using neural field theory;In: Journal of neuroscience methods,2016

3. A biophysical model of dynamic balancing of excitation and inhibition in fast oscillatory large-scale networks;In: PLoS computational biology,2018

4. Cerebral electrometabolic coupling in disordered and normal states of consciousness;In: Cell Reports,2023

5. Clinical and neurophysiological effects of central thalamic deep brain stimulation in the minimally conscious state after severe brain injury;In: Scientific reports,2022

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