Cyclocarya paliuruspolysaccharides improve high fat diet-fed mice lipid dysmetabolism through gut microbiota

Abstract

AbstractObesity is associated with low-grade chronic inflammation and intestinal dysbiosis.Cyclocarya paliurus(C.paliurus) has been shown to improve lipid metabolism and gut microbiota communities in animals and humans; however, it remains to know whetherCyclocarya paliuruspolysaccharides (CCPP) prevents obesity through gut microbiota. Here, we found that high fat diet promoted the lipid accumulation and intestinal microbiota dysbiosis in mice, while drinkCyclocarya paliuruspolysaccharides reduces body weight, inflammation, alleviated the lipid accumulation, and reversed gut microbiota dysbiosis, including the diversity of intestinal microbiota, relative abundances ofLachnospiraceae. By transplanting faeces from CP-treated mice to HFD-fed mice, the effects of anti-obesity and microbiome regulation can be transferred through gut microbiota. Our results indicate thatCyclocarya paliuruspolysaccharides can prevent gut dysbiosis and obesity-related metabolic disorders in obese individuals, the mechanism is related to the remodeling of intestinal flora.