Topographical polarity reveals continuous EEG microstate transitions and electric field direction in healthy aging

Abstract

AbstractEEG microstate sequences, representing whole-brain spatial potential distribution patterns of the EEG, offer valuable insights for capturing spatiotemporally continuous and fluctuating neural dynamics with high temporal resolution through appropriate discretization. Recent studies suggest that EEG microstate transitions are gradual and continuous phenomena, contrary to the classical view of binary transitions. This study aimed to update conventional microstate analysis to reflect continuous EEG dynamics and examine differences in age-related electrophysiological state transitions. We considered the relative positions of EEG microstates on the neural manifold and their topographical polarity. Transition probability results showed fewer transitions on the microstate D-C-E axis in older adults. In contrast, transitions among microstates A, D, and B increased in the older group and were mainly observed within polarity. Furthermore, the 100 microstate transitions, which are variations of the shortest transitions between 10 microstates, could be reduced to 8 principal components based on the co-occurrence of each transition, including hubs C and E, planar transitions through msA/B and D, and unidirectional transition components. Several transition components were potentially significant predictors of age group. These features were nearly replicated in independent data, indicating their robustness in characterizing age-related electrophysiological spatiotemporal dynamics.