Ratiometric control of two microbial populations via a dual chamber bioreactor

Author:

Brancato Sara Maria,Salzano DavideORCID,Fiore DavideORCID,Russo GiovanniORCID,di Bernardo MarioORCID

Abstract

AbstractMaintaining stable coexistence in microbial consortia, particularly when one species grows faster than another (i.e. the species are non-complementary), poses significant challenges. We introduce a novel control architecture that employs two bioreactors. In this system, the slower-growing species is cultivated separately before being introduced into the main mixing chamber. We analyze the open-loop dynamics of this setup and propose a switching feedback mechanism that controls the dilution rates to ensure robust regulation of population density and composition within the microbial consortium. Validatedin silicousing parameters from real experiments, our approach demonstrates effective and robust maintenance of microbial balance across various strains without requiring genetic modifications.

Publisher

Cold Spring Harbor Laboratory

Reference20 articles.

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