The detrimental effect of stroke on motor adaptation

Abstract

AbstractBackgroundWhile it is evident that stroke impairs motor control, it remains unclear whether stroke impacts motor adaptation—the ability to flexibly modify movements in response to changes in the body and the environment. The mixed results in the literature may be due to differences in participants’ brain lesions, sensorimotor tasks, or a combination of both.ObjectiveWe first sought to better understand the overall impact of stroke on motor adaptation and then delineated the impact of lesion hemisphere and sensorimotor task on adaptation poststroke.MethodsFollowing the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines, we conducted a systematic review and meta-analysis of 17 studies comparing individuals poststroke to neurotypical controls, with each group consisting of over 200 participants.ResultsWe found that stroke impairs motor adaptation (d = −0.64; 95% CI [−1.06, −0.22]), and that the extent of this impairment did not differ across sensorimotor tasks but may vary with the lesioned hemisphere. Specifically, we observed greater evidence for impaired adaptation in individuals with left hemisphere lesions compared to those with right hemisphere lesions.ConclusionsThis review not only clarifies the detrimental effect of stroke on motor adaptation but also underscores the need for finer-grained studies to determine precisely how various sensorimotor learning mechanisms are impacted. The current findings may guide future mechanistic and applied research at the intersection of motor learning and neurorehabilitation.