Mental illness and COVID-19 vaccination: a multinational investigation of observational & register-based data
Author:
Barker Mary MORCID, Kõiv Kadri, Magnúsdóttir IngibjörgORCID, Milbourn Hannah, Wang Bin, Du Xinkai, Murphy Gillian, Herweijer Eva, Gísladóttir Elísabet U, Li Huiqi, Lovik AnikóORCID, Kähler Anna K., Campbell Archie, Feychting Maria, Hauksdóttir Arna, Joyce Emily E, Thordardottir Edda Bjork, Frans Emma M., Hoffart Asle, Mägi Reedik, Tómasson Gunnar, Ásbjörnsdóttir Kristjana, Jakobsdóttir Jóhanna, Andreassen Ole A.ORCID, Sullivan Patrick F., Johnson Sverre Urnes, Aspelund Thor, Brandlistuen Ragnhild Eek, Ask Helga, McCartney Daniel L, Ebrahimi Omid V, Lehto Kelli, Valdimarsdóttir Unnur A, Nyberg FredrikORCID, Fang FangORCID
Abstract
ABSTRACTBackgroundIndividuals with mental illness are at higher risk of severe COVID-19 outcomes. However, previous studies on the uptake of COVID-19 vaccination in this population have reported conflicting results. Therefore, we aimed to investigate the association between mental illness and COVID-19 vaccination uptake, using data from five countries.MethodsData from seven cohort studies (N=325,298), and the Swedish registers (8,080,234), were used to identify mental illness and COVID-19 vaccination uptake. Multivariable modified Poisson regression models were conducted to calculate the prevalence ratio (PR) and 95% CIs of vaccination uptake among individuals with v.s. without mental illness. Results from the cohort studies were pooled using random effects meta-analyses.FindingsMost of the meta-analyses performed using the COVIDMENT study population showed no significant association between mental illness and vaccination uptake. In the Swedish register study population, we observed a very small reduction in the uptake of both the first (prevalence ratio [PR]: 0.98, 95% CI: 0.98-0.99, p<0.001) and second dose among individuals with mental illness; the reduction was however greater among those not using pyschiatric medication (PR: 0.91, 95% CI: 0.91-0.91, p<0.001).ConclusionsThe high uptake of COVID-19 vaccination observed among individuals with most types of mental illness highlights the comprehensiveness of the vaccination campaign, however lower levels of vaccination uptake among subgroups of individuals with unmedicated mental illness warrants attention in future vaccination campaigns.
Publisher
Cold Spring Harbor Laboratory
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