Author:
Tung Hwai-Ray,Durrett Rick
Abstract
AbstractWe investigate the site frequency spectrum in the two-type model of clonal evolution. If the fitnesses of the two types are λ0 < λ1 then the site frequency spectrum is c/fα where α = λ0/λ1. This is due to the advantageous mutations that produce the founders of the type 1 population. Mutations within the growing type 0 and type 1 populations follow the 1/f law. Our results show that neutral evolution can be distinguished from the two-type model using the site frequency spectrum.
Publisher
Cold Spring Harbor Laboratory
Reference14 articles.
1. Revisiting signatures of neutral tumor evolution in light of the complexity of genomic data;Nature Genetics,2018
2. Accumulation of driver and passenger mutations during tumor progression
3. On measuring selection in cancer from subclonal mutation frequencies;PLoS Computational Biology,2019
4. Population genetics of neutral mutations in exponentially growing cancer cell populations;Ann. Appl. Probab,2012
5. Durrett, R. (2015) Branching Process Models of Cancer. Published by Springer