Author:
Desai Niyati,Neyaz Azfar,Szabolcs Annamaria,Shih Angela R.,Chen Jonathan H.,Thapar Vishal,Nieman Linda T.,Solovyov Alexander,Mehta Arnav,Lieb David J.,Kulkarni Anupriya S.,Jaicks Christopher,Pinto Christopher J.,Juric Dejan,Chebib Ivan,Colvin Robert B.,Kim Arthur Y.,Monroe Robert,Warren Sarah E,Danaher Patrick,Reeves Jason W,Gong Jingjing,Rueckert Erroll H,Greenbaum Benjamin D.,Hacohen Nir,Lagana Stephen M.,Rivera Miguel N.,Sholl Lynette M.,Stone James R.,Ting David T.,Deshpande Vikram
Abstract
ABSTRACTThe relationship of SARS-CoV-2 lung infection and severity of pulmonary disease is not fully understood. We analyzed autopsy specimens from 24 patients who succumbed to SARS-CoV-2 infection using a combination of different RNA and protein analytical platforms to characterize inter- and intra-patient heterogeneity of pulmonary virus infection. There was a spectrum of high and low virus cases that was associated with duration of disease and activation of interferon pathway genes. Using a digital spatial profiling platform, the virus corresponded to distinct spatial expression of interferon response genes and immune checkpoint genes demonstrating the intra-pulmonary heterogeneity of SARS-CoV-2 infection.
Publisher
Cold Spring Harbor Laboratory
Cited by
16 articles.
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