Abstract
Development of the ovary or testis is required to establish reproductive competence. Gonad development relies on key cell fate decisions that occur early in embryonic development and are actively maintained. During gonad development, both germ cells and somatic cells proliferate extensively, a process facilitated by cell cycle regulation. This review focuses on the Cip/Kip family of cyclin-dependent kinase inhibitors (CKIs) in mouse gonad development. We particularly highlight recent single-cell RNA sequencing studies that show the heterogeneity of cyclin-dependent kinase inhibitors. This diversity highlights new roles for cell cycle inhibitors in controlling and maintaining female fertility.
Funder
Cancer Research UK
UK Medical Research Council
Wellcome Trust
Biotechnology and Biological Sciences Research Council
National Health and Medical Research Council
Hunter Medical Research Institute
Publisher
Cold Spring Harbor Laboratory
Subject
Developmental Biology,Genetics
Cited by
12 articles.
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