SNP Identity Searching Across Ethnicities, Kinship, and Admixture

Abstract

ABSTRACTAdvances in high throughput sequencing (HTS) enables application of single nucleotide polymorphism (SNP) panels for identification and mixture analysis. Large reference sets of characterized individuals with documented relationships, ethnicities, and admixture are not yet available for characterizing the impacts of different ethnicities, kinships, and admixture on identification and mixture search results for relatives and unrelated individuals. Models for the expected results are presented with comparison results on two in silico datasets spanning four ethnicities, extended kinship relationships, and also admixture between the four ethnicities.