Author:
Deng Wensheng,Roberts Stefan G.E.
Abstract
We have defined a core promoter element downstream of the TATA box that is recognized by TFIIB. This involves a DNA-binding domain in TFIIB that is distinct from the helix–turn–helix motif (which recognizes an element upstream of the TATA box). The TFIIB recognition element we describe regulates transcription in a manner that is promoter context-dependent, particularly with respect to the TFIIB recognition element that is located upstream of the TATA box. Thus TFIIB can recognize two distinct sequence elements that flank the TATA box, employing independent DNA-binding motifs and cooperating in the regulation of transcription.
Publisher
Cold Spring Harbor Laboratory
Subject
Developmental Biology,Genetics
Reference22 articles.
1. Ausubel F.M ., Brent, R., Kingston, R.E., Moore, D.D., Seidman, J.G., Smith, J.A., and Struhl, K. 1995. Short protocols in molecular biology, pp. 12.9-12.11. Wiley, New York.
2. Identification and Distinct Regulation of Yeast TATA Box-Containing Genes
3. Orientation of the transcription preinitiation complex in Archaea
4. Role of the RNA polymerase sigma subunit in transcription initiation
5. The RNA polymerase II core promoter: a key component in the regulation of gene expression
Cited by
125 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献