Inducing a meditative state by artificial perturbations: A causal mechanistic understanding of brain dynamics underlying meditation

Abstract

AbstractContemplative neuroscience has increasingly explored meditation using neuroimaging. However, the brain mechanisms underlying meditation remain elusive. Here, we implemented a causal mechanistic framework to explore the spatiotemporal dynamics of expert meditators during meditation and rest. We first applied a model-free approach by defining a probabilistic metastable substate (PMS) space for each state, consisting of different probabilities of occurrence from a repertoire of dynamic patterns. Different brain signatures were mainly found in the triple-network model (i.e., the executive control, salience, and default-mode networks). Moreover, we implemented a model-based approach by adjusting the PMS of the resting state to a whole-brain model, which enabled us to explorein silicoperturbations to transition to the meditation state. Consequently, we assessed the sensitivity of different brain areas regarding their perturbability and their mechanistic local-global effects. Using a synchronous protocol, we successfully transitioned from the resting state to the meditative state by shifting areas mainly from the somatomotor and dorsal attention networks. Overall, our work reveals distinct whole-brain dynamics in meditation compared to rest, and how the meditation state can be induced with localized artificial perturbations. It motivates future work regarding meditation as a practice in health and as a potential therapy for brain disorders.