Author:
Qin SiHao,Wang Xueyao,Li Huan,Jiang YanFang
Abstract
SUMMARYCeO2can consume intracellular reducing power, but its poor biocompatibility limits its application in tumor therapy. In this study, we designed and synthesized DSPE-PEG-CeO2, which is easy to enter cells, and showed that DSPE-PEG-CeO2can induce the increase of ROS levels in tumor cells, thereby inducing tumor cell apoptosis and DNA damage. This suppresses the appearance and development of tumor cells. This provides a new idea for the application of inorganic nanomaterials.
Publisher
Cold Spring Harbor Laboratory