“In silicocharacterization of Protein L-Iso-Aspartate-O-Methyltransferases (PIMT) ofShigella flexneri”

Abstract

AbstractThere are only a few protein repair enzymes known. One of them, Protein Iso-Aspartate Methyltransferases (PIMT), also known as Protein Carboxyl Methyltransferases (PCMT), is responsible for converting Iso-Aspartate (abnormal amino acid residues) to Aspartate (normal amino acid residues). PCMT is an enzyme found in a wide range of living organisms. In the present study, the amino acid sequence of PIMT ofShigella flexneriwas retrieved and the 3D structure is predicted. Further, it is characterized byin silicoapproaches and its interaction with one of the target proteinsi. e. rpoS is studied.