Effect of a topically applied gel containing antibodies from bovine milk on the relative abundance of Staphylococci in the canine skin microbiome

Abstract

AbstractCanine pyoderma is characterised by a predominant colonisation of the skin withStaphylococcus pseudintermediusand inflammatory symptoms associated with it. Immunoglobulins isolated from cow’ ss milk are neutralizing virulence factors and toxins ofS. pseudintermedius. In a pilot study with four dogs with pyoderma we were able to show that the application of immunoglobulin gel leads to a decrease in the staphylococcal population and an increase in the diversity of the skin microbiome.Due to the limited number of animals, the measurable effect is not statistically significant. Therefore, we are planning a follow-up study that includes more animals.