Algorithmic Fairness in Computational Medicine

Abstract

ABSTRACTMachine learning models are increasingly adopted for facilitating clinical decision-making. However, recent research has shown that machine learning techniques may result in potential biases when making decisions for people in different subgroups, which can lead to detrimental effects on the health and well-being of vulnerable groups such as ethnic minorities. This problem, termed algorithmic bias, has been extensive studied in theoretical machine learning recently. However, how it will impact medicine and how to effectively mitigate it still remains unclear. This paper presents a comprehensive review of algorithmic fairness in the context of computational medicine, which aims at improving medicine with computational approaches. Specifically, we overview the different types of algorithmic bias, fairness quantification metrics, and bias mitigation methods, and summarize popular software libraries and tools for bias evaluation and mitigation, with the goal of providing reference and insights to researchers and practitioners in computational medicine.