Abstract
AbstractUnderstanding how plants adapt their physiology to overcome severe stress conditions is vital in light of the current climate crisis. This remains a challenge given the complex nature of the underlying molecular mechanisms. To provide a full picture of stress mitigation mechanisms, an exhaustive analysis of publicly available stress-related transcriptomic data was conducted. We combined a meta-analysis with an unsupervised machine learning algorithm to identify a core of stress-related genes. To ensure robustness and biological significance of the output, often lacking in meta-analyses, a three-layered biovalidation was incorporated. Our results present a ‘stress gene core’, a set of key genes involved in plant tolerance to a multitude of adverse environmental conditions rather than specific ones. In addition, we provide a biologically validated database to assist in design of multi-stress resilience. Taken together, our results pave the way towards future-proof sustainable agriculture.TeaserUsing a machine learning-driven meta-analysis, a plant ‘stress gene core’ was identified as a hub mediating multi-stress regulation
Publisher
Cold Spring Harbor Laboratory
Reference143 articles.
1. Food and Agriculture Organization of the United Nations, The impact of disasters and crises on agriculture and food security: 2021 (Food & Agriculture Org., 2021).
2. P. Pandey , V. Irulappan , M. V. Bagavathiannan , M. Senthil-Kumar , Impact of Combined Abiotic and Biotic Stresses on Plant Growth and Avenues for Crop Improvement by Exploiting Physio-morphological Traits. Frontiers in Plant Science. 8 (2017).
3. S. O. Oshunsanya , N. J. Nwosu , Y. Li , Abiotic Stress in Agricultural Crops Under Climatic Conditions. Sustainable Agriculture, Forest and Environmental Management (2019), pp. 71–100.
4. The global burden of pathogens and pests on major food crops;Nat Ecol Evol,2019
5. Thriving under Stress: How Plants Balance Growth and the Stress Response