Investigate the causality and genetic association between migraine and Parkinson’s disease

Abstract

AbstractBackgroundThe relationship between migraine and Parkinson’s disease (PD) remains controversial. We intend to investigate the causal and genetic association between migraine and PD.MethodsData related to migraine [any migraine (AM), migraine without aura (MO), and migraine with aura (MA)] and PD were respectively obtained from the latest Genome-wide meta-analysis conducted by the International Headache Genetics Consortium and the International Parkinson’s Disease Genomics Consortium. Univariate Mendelian Randomization (UMR) and multivariate MR (MVMR) were conducted to estimate their bidirectional causality, and global/local genetic correlation and tissue expression analyses were utilized to assess their genetic associations.ResultsThe UMR presented that AM (OR: 1.016, 95% CI: 0.908-1.135,p= 0.785), MO (OR: 0.944, 95% CI: 0.836-1.067,p= 0.358) and MA (OR: 1.006, 95% CI: 0.951, 1.064,p= 0.846) were unlikely to be associated with PD risk. Similarly, the reverse UMR analyses demonstrated that PD was unrelated to the risks of migraine and its subtypes. These null associations were supported by the MVMR when adjusted for coronary heart disease and hypertension. The global genetic correlation analyses presented that AM (rg= -0.061,p= 0.127), MA (rg= -0.047,p= 0.516), MO (rg= -0.063,p= 0.492) were generally not related to PD, and the local genetic correlation analyses shown they were also uncorrelated in any region. Additionally, the tissue expression analyses found they had no shared tissues.ConclusionThis study suggested no causality or association between migraine and PD from the genetic perspective.