Transposon fusion gave birth toFem,Bombyx morifemale determining gene

Author:

Lee JungORCID,Fujimoto Toshiaki,Yamaguchi Katsushi,Shigenobu Shuji,Sahara Ken,Toyoda Atsushi,Shimada ToruORCID

Abstract

AbstractFemis a W-linked piRNA precursor, andFempiRNA is a master gene of female determination inBombyx mori. SinceFemhas significantly low similarity to any known sequences and the origin ofFemremains unclear, two hypotheses have been proposed for the origin ofFem. The first one is thatFemis an allele ofMasc,while the second one is thatFemarose by transposition ofMasc. To draw a solid conclusion, we determined the W chromosome sequences ofB. moriand a closely relative bombycid species ofTrilocha varianswith aFem-independent sex determination system. Comprehensive genome comparison led us to the “third” hypothesis:Femis a chimeric sequence of transposons. Although we still cannot completely exclude the first hypothesis, at least a large portion of the parts other than the 44-bpMascsimilarity region is derived from transposons, and even the 44-bp region could correspond to the boundary of the two transposons, gypsy and satellite DNA.

Publisher

Cold Spring Harbor Laboratory

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