Identifying alterations in hand movement coordination from chronic stroke survivors using a wearable high-density EMG sleeve

Abstract

AbstractNon-invasive, high-density electromyography (HD-EMG) has emerged as a useful tool to collect a range of neurophysiological motor information. Recent studies have demonstrated changes in EMG features that occur after stroke, which correlate with functional ability, highlighting their potential use as biomarkers. However, previous studies have largely explored these EMG features in isolation with individual electrodes to assess gross movements, limiting their potential clinical utility. Here, able-bodied (N=7) and chronic stroke subjects (N=7) performed 12 functional hand and wrist movements while HD-EMG was recorded using a wearable sleeve. We demonstrate that a variety of HD-EMG features, or views, can be decomposed from the wearable sleeve. Stroke subjects, on average, had higher co-contraction and reduced muscle coupling when attempting to open their hand and actuate their thumb. In an expanded dataset consisting of 37 movements, we characterized muscle synergies in the forearm of able-bodied individuals. We found that the high-density array provides additional resolution over manually placed electrodes, which may help dissociate finer nuances in motor control. Additionally, muscle synergies decomposed in the stroke population were relatively preserved, with a large spatial overlap in composition of matched synergies. Alterations in synergy composition demonstrated reduced coupling between digit extensors and muscles that actuate the thumb, as well as an increase in flexor activity in the stroke group. Average synergy activations during movements revealed differences in coordination, highlighting overactivation of antagonist muscles and compensatory strategies. When combining co-contraction and muscle synergy features, the first principal component was correlated with upper-extremity Fugl Meyer hand sub-score of stroke participants (R2=0.86). Principal component embeddings of individual features revealed interpretable measures of motor coordination and muscle coupling alterations. These results demonstrate the feasibility of predicting motor function through features decomposed from a wearable HD-EMG sleeve, which could be leveraged to improve stroke research and clinical care.