Author:
Gough Ethan K,Edens Thaddeus J,Carr Lynnea,Robertson Ruairi C,Mutasa Kuda,Ntozini Robert,Chasekwa Bernard,Geum Hyun Min,Baharmand Iman,Gill Sandeep K,Mutasa Batsirai,Mbuya Mduduzi N N,Majo Florence D,Tavengwa Naume,Francis Freddy,Tome Joice,Evans Ceri,Kosek Margaret,Prendergast Andrew J,Manges Amee R,
Abstract
SummaryChild stunting is an indicator of chronic undernutrition and reduced human capital. Small-quantity lipid-based nutrient supplements (SQ-LNS) has been widely tested to reduce stunting, but has modest effects. The infant intestinal microbiome may contribute to stunting, and is partly shaped by mother and infant histo-blood group antigens (HBGA). We investigated whether mother-infant fucosyltransferase status, which governs HBGA, and the infant gut microbiome modified the impact of SQ-LNS on stunting at age 18 months among Zimbabwean infants in the SHINE Trial (NCT01824940). We found that mother-infant fucosyltransferase discordance andBifidobacterium longummodified SQ-LNS efficacy. Infant age-related microbiome shifts inB. longumsubspecies dominance frominfantis, a proficient human milk oligosaccharide utilizer, tosuisorlongum, proficient plant-polysaccharide utilizers, were partly influenced by discordance in mother-infant FUT2+/FUT3-phenotype, suggesting that a “younger” microbiome at initiation of SQ-LNS reduces its benefits on stunting in areas with a high prevalence of linear growth restriction.
Publisher
Cold Spring Harbor Laboratory
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