SCIseg: Automatic Segmentation of T2-weighted Intramedullary Lesions in Spinal Cord Injury

Abstract

AbstractPurposeTo develop a deep learning tool for the automatic segmentation of T2-weighted intramedullary lesions in spinal cord injury (SCI).Material and MethodsThis retrospective study included a cohort of SCI patients from three sites enrolled between July 2002 and February 2023. A deep learning model,SCIseg, was trained in a three-phase process involving active learning for the automatic segmentation of intramedullary SCI lesions and the spinal cord. The data consisted of T2-weighted MRI acquired using different scanner manufacturers with heterogeneous image resolutions (isotropic/anisotropic), orientations (axial/sagittal), lesion etiologies (traumatic/ischemic/hemorrhagic) and lesions spread across the cervical, thoracic and lumbar spine. The segmentations from the proposed model were visually and quantitatively compared with other open-source baselines. Wilcoxon signed-rank test was used to compare quantitative MRI biomarkers (lesion volume, lesion length, and maximal axial damage ratio) computed from manual lesion masks and those obtained automatically withSCIsegpredictions.ResultsMRI data from 191 SCI patients (mean age, 48.1 years ± 17.9 [SD]; 142 males) were used for model training and evaluation. SCIseg achieved the best segmentation performance for both the cord and lesions. There was no statistically significant difference between lesion length and maximal axial damage ratio computed from manually annotated lesions and those obtained usingSCIseg.ConclusionAutomatic segmentation of intramedullary lesions commonly seen in SCI replaces the tedious manual annotation process and enables the extraction of relevant lesion morphometrics in large cohorts. The proposed model segments lesions across different etiologies, scanner manufacturers, and heterogeneous image resolutions.SCIsegis open-source and accessible through the Spinal Cord Toolbox.SummaryAutomatic segmentation of the spinal cord and T2-weighted lesions in spinal cord injury on MRI scans across different treatment strategies, lesion etiologies, sites, scanner manufacturers, and heterogeneous image resolutions.Key ResultsAn open-source, automatic method,SCIseg, was trained and evaluated on a dataset of 191 spinal cord injury patients from three sites for the segmentation of the spinal cord and T2-weighted lesions.SCIseggeneralizes across traumatic and non-traumatic lesions, scanner manufacturers, and heterogeneous image resolutions, enabling the automatic extraction of lesion morphometrics in large multi-site cohorts.Quantitative MRI biomarkers, namely, lesion length and maximal axial damage ratio derived from the automatic predictions showed no statistically significant difference when compared with manual ground truth, implying reliability inSCIseg’spredictions.