Human promoter CpG islands contain primate-specific repeats, cluster and resist reprogramming

Author:

Mohan K Naga,Anne Anuhya,Kumar Lov,Chaillet J RichardORCID

Abstract

AbstractImperfect tandem repeats (TRs) of ≥400nt are associated with 365 human 5’-genic CpG islands (TR-CGIs). Most are clustered at chromosome ends, with a high density across chromosome 19. These genes are enriched in neurodevelopmental/behavioral disorders and show interindividual variation in methylation levels. A subset of TR-CGIs is highly methylated and remains so during reprogramming to primed iPSCs, but become unmethylated in naïve PSCs, as do imprinting control regions (ICRs). Transcript levels correlate with methylation for some TR-CGI genes. TR-CGIs occur as orthologs in primates, but the corresponding mouse promoter-CGIs are without TRs and unmethylated. Thus, non-imprinted TR-CGIs accompanied primate evolution, with unique ability to acquire methylation during embryonic development and resist reprogramming to a pluripotent stem cell state.One-Sentence SummaryDNA unique to human and non-human primate genes can acquire lifelong CpG methylation mid-course to redirect fetal development.

Publisher

Cold Spring Harbor Laboratory

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3