A Genetic Perspective on Diabetic Complications: A Mendelian Randomization Study on the Increased Risk of Cataracts in Type 1 Diabetes

Abstract

AbstractBackgroundThe well-documented epidemiological link between type 1 diabetes and cataract is recognized. Yet, the question of a shared genetic foundation for these conditions, and the potential implication of a causal connection, is still an area of uncertainty.MethodsWe utilized a two-sample Mendelian randomization approach to extract and analyze four GWAS datasets from public databases, aiming to elucidate the causal relationship between Type 1 Diabetes and cataracts. Our study design incorporated multiple Mendelian randomization methods to assess the influence of Type 1 Diabetes genetic risk on the susceptibility to cataracts, and employed the MR-PRESSO global test for the evaluation of horizontal heterogeneity among the results.ResultsMendelian Randomization analysis has indicated a statistically significant association between Type 1 Diabetes and an increased risk of cataract development. All applied Mendelian Randomization methods pointed to a positive causal estimate, suggesting that Type 1 Diabetes contributes to an elevated risk of cataracts.ConclusionThis study supports the hypothesis of a causal relationship between Type 1 Diabetes and cataracts. Despite some heterogeneity, all outcomes are positively aligned, and leave-one-out analysis confirms the robustness of these findings. This research is significant for understanding the process of cataract prevention and treatment in patients with Type 1 Diabetes.