Author:
Tang Cerise,Castillon Venise Jan,Waters Michele,Fong Chris,Park Tricia,Boscenco Sonia,Kim Susie,Schultz Nikolaus,Ostrovnaya Irina,Gusev Alexander,Jee Justin,Reznik Ed
Abstract
AbstractObesity is a leading risk factor for cancer, but whether obesity is linked to specific genomic subtypes of cancer is unknown. Here, we examined the relationship between obesity and tumor genotype in two large clinicogenomic corpora. Obesity was associated with specific driver mutations in lung adenocarcinoma, endometrial carcinoma, and cancers of unknown primary, independent of clinical covariates and genetic ancestry. Obesity is therefore a putative driver of etiologic heterogeneity across cancers.
Publisher
Cold Spring Harbor Laboratory