Uniquome: Construction and Decoding of a Novel Proteomic Atlas that Contains New Peptide Entities

Author:

Kontopodis Evangelos,Pierros Vasileios,Vorgias Constantinos E.,Papassideri Issidora S.,Stravopodis Dimitrios J.,Tsangaris George Th.ORCID

Abstract

AbstractCellular and molecular uniqueness has recently gained eminent importance, due to the large amount of data produced by “-omics” technologies. Herein, we have constructed and decoded the “Uniquome”, by introduction of the new peptide entities: (a) “Core Unique Peptide” (CrUP), defined as the peptide whose sequence is accommodated, specifically and exclusively, only in one protein in a given proteome, and also bears the minimum length of amino acid sequence; (b) “Composite Unique Peptide” (CmUP), defined as the peptide composed by the linear unification of CrUPs, when two or more successive in order CrUPs overlap one another; (c) “Family Unique Peptide” (FUP), defined as the CrUPs that are common between all members of a given family, but unique only for the protein members of the particular family, and (d) “Universal Unique Peptides” (UUPs), which are the common CrUPs in a given protein across organisms, carrying the important ability to securely identify a protein independently of an organism. By these entities as tool-box, we have analyzed the human and model organisms, respective, proteomes. We demonstrate that these novel peptide entities play a crucial role for protein identification, protein-function prediction, cell physiology, tissue pathology, therapeutic oncology and translational medicine. Finally, we suggest that across species the conserved sequences are not DNA nucleotides but CrUPs entities.One-Sentence SummaryWe constructed and decoded the “Uniquome”, by introducing the new peptide entities Core Unique Peptide, Composite Unique Peptide, Family Unique Peptide and Universal Unique Peptide

Publisher

Cold Spring Harbor Laboratory

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