Uniquome: Construction and Decoding of a Novel Proteomic Atlas that Contains New Peptide Entities

Author:

Kontopodis Evangelos,Pierros Vasileios,Vorgias Constantinos E.,Papassideri Issidora S.,Stravopodis Dimitrios J.,Tsangaris George Th.ORCID

Abstract

AbstractCellular and molecular uniqueness has recently gained eminent importance, due to the large amount of data produced by “-omics” technologies. Herein, we have constructed and decoded the “Uniquome”, by introduction of the new peptide entities: (a) “Core Unique Peptide” (CrUP), defined as the peptide whose sequence is accommodated, specifically and exclusively, only in one protein in a given proteome, and also bears the minimum length of amino acid sequence; (b) “Composite Unique Peptide” (CmUP), defined as the peptide composed by the linear unification of CrUPs, when two or more successive in order CrUPs overlap one another; (c) “Family Unique Peptide” (FUP), defined as the CrUPs that are common between all members of a given family, but unique only for the protein members of the particular family, and (d) “Universal Unique Peptides” (UUPs), which are the common CrUPs in a given protein across organisms, carrying the important ability to securely identify a protein independently of an organism. By these entities as tool-box, we have analyzed the human and model organisms, respective, proteomes. We demonstrate that these novel peptide entities play a crucial role for protein identification, protein-function prediction, cell physiology, tissue pathology, therapeutic oncology and translational medicine. Finally, we suggest that across species the conserved sequences are not DNA nucleotides but CrUPs entities.One-Sentence SummaryWe constructed and decoded the “Uniquome”, by introducing the new peptide entities Core Unique Peptide, Composite Unique Peptide, Family Unique Peptide and Universal Unique Peptide

Publisher

Cold Spring Harbor Laboratory

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. A survey of k-mer methods and applications in bioinformatics;Computational and Structural Biotechnology Journal;2024-12

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3