Author:
Jain Miten,Olsen Hugh E.,Turner Daniel J.,Stoddart David,Bulazel Kira V.,Paten Benedict,Haussler David,Willard Huntington F.,Akeson Mark,Miga Karen H.
Abstract
The human genome reference sequence remains incomplete due to the challenge of assembling long tracts of near-identical tandem repeats-in centromeric regions. To address this, we have implemented a nanopore sequencing strategy to generate high quality reads that span hundreds of kilobases of highly repetitive DNAs. Here, we use this advance to produce a sequence assembly and characterization of the centromeric region of a human Y chromosome.
Publisher
Cold Spring Harbor Laboratory
Cited by
4 articles.
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