Active Conservation of Noncoding Sequences Revealed by Three-Way Species Comparisons

Author:

Dubchak Inna,Brudno Michael,Loots Gabriela G.,Pachter Lior,Mayor Chris,Rubin Edward M.,Frazer Kelly A.

Abstract

Human and mouse genomic sequence comparisons are being increasingly used to search for evolutionarily conserved gene regulatory elements. Large-scale human–mouse DNA comparison studies have discovered numerous conserved noncoding sequences of which only a fraction has been functionally investigated A question therefore remains as to whether most of these noncoding sequences are conserved because of functional constraints or are the result of a lack of divergence time.[The sequence data described in this paper have been submitted to the GenBank data library under accession nos. AF276990.]

Publisher

Cold Spring Harbor Laboratory

Subject

Genetics (clinical),Genetics

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