Author:
Bjorness Theresa E.,Riley Brett T.,Tysor Michael K.,Poe Gina R.
Abstract
We tested the hypothesis that rapid eye movement (REM) sleep is important
for complex associative learning by restricting rats from entering REM sleep
for 4 h either immediately after training on an eight-box spatial task (0-4
REMr) or 4 h following training (4-8 REMr). Both groups of REM-restricted rats
eventually reached the same overall performance level as did nonrestricted
controls, but 0-4 REMr animals were delayed in their improvement in the first
few days and lagged behind controls in the middle portion of the training
period. More importantly, performance gains of 0-4 REMr rats depended more on
simple local cues throughout the 15-d study since, unlike control and 4-8 REMr
animals, their error rate increased after daily disruption of the relationship
between local (intramaze) cues and the food reward. Thus, although overall
performance was only subtly and transiently impaired, due to the ability to
use alternate, nonspatial behavioral strategies, complex associative (spatial)
learning was persistently impaired by restricting REM for a short critical
period each day.
Publisher
Cold Spring Harbor Laboratory
Subject
Cellular and Molecular Neuroscience,Cognitive Neuroscience,Neuropsychology and Physiological Psychology
Cited by
59 articles.
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