Coronary artery disease and prostate cancer share a common genetic risk mediated through Lipoprotein(a)

Abstract

Brief unreferenced abstractThe genetics underlying cancer and cardiovascular disease have been studied for decades. However, despite sharing numerous risk factors and pathologic features, the contribution of shared genetics in these diseases remains poorly defined. Our study sought to identify common genetic factors between these two diseases. We found a unique relationship between coronary artery disease and prostate cancer that appears to be mediated through germline genetic variation in LPA.