Comparison of LIAISON QuantiFERON-TB Gold Plus with QuantiFERON-TB Gold Plus

Abstract

AbstractWith the large global burden of latent tuberculosis (TB) infection (LTBI), screening for LTBI for various reasons has become standard practice including the low-prevalence settings.The results showed acceptable intra- and inter-run precision as well as cutoff verification across the two analyzers at the afore-mentioned levels (Table 1). Overall, the LIAISON QFT-Plus showed better inter- and intra-run precision compared with QFT-Plus when comparing low-positive TB1/2 samples; however, coefficient of variation (CVs) less than 20% are generally acceptable for any automated test. Cutoff verification showed CVs for QFT-Plus TB1 and TB2, QFT-Plus LIAISON TB1 and TB2 of 5.2%, 4.1%, 5.2%, 5.4%, respectively, demonstrating robustness around the cutoffs.Altogether, the two methods were highly comparable. LIAISON QFT-Plus is a suitable alternative to batch testing (e.g., using DSX) in high-volume laboratories.