Photocontrolled Release of Nitric Oxide for Precise Management of NO Concentration in a Solution

Abstract

AbstractNitric oxide (NO) is a unique biochemical mediator involved in the regulation of vital processes. Its short half-life and local action impede direct application in medical practice. Light-controllable NO releasers are promising for the development of smart therapies. Here we present novel aza-BODIPY derivative containingN-nitroso moiety, which shows efficient and reversible release of NO under red light. Using this molecule, we demonstrate a system for precise management of NO concentration in aqueous solutionin vitrousing the feedback loop with optical control. Our results could serve as the basis for the development of novel therapeutic methods.