Author:
Ji Jiamin,Zheng Kailing,He Miao
Abstract
SummaryTo align the dynamic protein-protein interaction networks (DPINs) might help to better understand the molecular network genetic mechanisms of flower development inArabidopsis thaliana. In this paper, the microarray data of flower development inArabidopsiswere obtained from the gene expression omnibus (GEO) database. The active expressed genes at each time point were screened using σ method. The DPIN at each time point were reconstructed using search tool for the retrieval of interacting genes/proteins (STRING) and then visualized with Cytoscape, and enrichment analysis implemented using clusterProfiler package of the R language. We improved NetCoffee 2, a multi-time, multidimensional, and multi-level network alignment algorithm, NetCoffee 2+, was developed for floral development of A. thaliana. In this paper, a network alignment algorithm applied toA. thaliana, NetCoffee 2+, was developed, and the key proteins and protein complexes during floral development inA. thalianawere mined, with new potential ABCDE-like genes discovered.
Publisher
Cold Spring Harbor Laboratory