Prospective evaluation of dRAST for selecting optimal targeted antibiotics in positive blood culture with Gram-positive organisms

Abstract

AbstractEmpirical antibiotic selection often fails to be optimal targeted in the era of increasingly common resistant organisms. We prospectively evaluated the usefulness or rapid AST for optimal antibiotic selection by infectious disease (ID) physicians in patients with bacteremia of Gram-positive organisms. QMAC-dRAST results led to optimal antibiotic treatment in 33 (89.2%) of the 37 cases receiving non-optimal targeted antibiotics. Optimal targeted treatments based on QMAC-dRAST results were possible in 133 (97.1%) of the 137 cases. In conclusion, the introduction of rapid phenotypic AST can help increase the selection of optimal targeted antibiotics during the early period of bacteremia.