Author:
Chang Cheng,Goel Hira Lal,Gao Huijie,Pursell Bryan,Shultz Leonard D.,Greiner Dale L.,Ingerpuu Sulev,Patarroyo Manuel,Cao Shiliang,Lim Elgene,Mao Junhao,McKee Karen Kulju,Yurchenco Peter D.,Mercurio Arthur M.
Abstract
Understanding how the extracellular matrix impacts the function of cancer stem cells (CSCs) is a significant but poorly understood problem. We report that breast CSCs produce a laminin (LM) 511 matrix that promotes self-renewal and tumor initiation by engaging the α6Bβ1 integrin and activating the Hippo transducer TAZ. Although TAZ is important for the function of breast CSCs, the mechanism is unknown. We observed that TAZ regulates the transcription of the α5 subunit of LM511 and the formation of a LM511 matrix. These data establish a positive feedback loop involving TAZ and LM511 that contributes to stemness in breast cancer.
Funder
National Institutes of Health
Publisher
Cold Spring Harbor Laboratory
Subject
Developmental Biology,Genetics
Cited by
125 articles.
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