Author:
Li Jiexi,Ma Xingdi,Chakravarti Deepavali,Shalapour Shabnam,DePinho Ronald A.
Abstract
Colorectal cancer has served as a genetic and biological paradigm for the evolution of solid tumors, and these insights have illuminated early detection, risk stratification, prevention, and treatment principles. Employing the hallmarks of cancer framework, we provide a conceptual framework to understand how genetic alterations in colorectal cancer drive cancer cell biology properties and shape the heterotypic interactions across cells in the tumor microenvironment. This review details research advances pertaining to the genetics and biology of colorectal cancer, emerging concepts gleaned from immune and single-cell profiling, and critical advances and remaining knowledge gaps influencing the development of effective therapies for this cancer that remains a major public health burden.
Funder
Cancer Prevention and Research Institute of Texas
Research Training Program
Triumph
CPRIT
Digestive Disease Center-National Institute of Diabetes and Digestive and Kidney Diseases
National Institutes of Health
National Institute on Alcohol Abuse and Alcoholism
NIH
MD Anderson SPORE in Gastrointestinal Cancer
Harry Graves Burkhart III Distinguished University Chair in Cancer Research
Publisher
Cold Spring Harbor Laboratory
Subject
Developmental Biology,Genetics
Cited by
242 articles.
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