FGFR1 tyrosine kinase domain duplication in pilocytic astrocytoma with anaplasia-Reference-Cited by-同舟云学术

FGFR1 tyrosine kinase domain duplication in pilocytic astrocytoma with anaplasia

Published:2018-04 Issue:2 Volume:4 Page:a002378
ISSN:2373-2865
Container-title:Molecular Case Studies
language:en
Short-container-title:Cold Spring Harb Mol Case Stud

Author:

Ballester Leomar Y.,Penas-Prado Marta,Leeds Norman E.,Huse Jason T.,Fuller Gregory N.

Abstract

We report the case of a 27-yr-old male with visual field loss who had a 4.9-cm complex cystic mass in the right occipital lobe. Histologic examination showed pilocytic astrocytoma (PA) with anaplasia, and molecular characterization revealed FGFR1 duplication with additional variants of unknown significance in several genes (ARID1A, ARID1B, CHEK2, EPHA5, and MLL2). This is one of only a very few reported cases of anaplastic PA with characterization of molecular alterations.

Publisher

Cold Spring Harbor Laboratory

Subject

General Medicine

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