Simple and Versatile Pharmacokinetic Model for Radioligand Therapy-Reference-Cited by-同舟云学术

Simple and Versatile Pharmacokinetic Model for Radioligand Therapy

Published:2024-06-13 Issue: Volume: Page:
ISSN:
Container-title:
language:
Short-container-title:

Author:

Zounek Adrian Jun^ORCID,Zounek Alexis Nikolai

Abstract

AbstractIn recent years radioligand therapy has emerged as an effective treatment modality for various solid malignancies, with pharmacokinetic modeling being routinely used for absorbed dose calculation and patient-specific therapy planning. Exemplary time-activity curves of FAP-targeted radioligands in a mouse model are accurately fitted by a sum of right skew biexponential distributions with four adjustable parameters in total. This type of modeling function is versatile and also suitable for conventional drugs. For further insight, an auxiliary equation is derived that relates tumor clearance to FAP expression and the radioligand dissociation constant.

Publisher

Cold Spring Harbor Laboratory

Reference15 articles.

1. Skewed Double Exponential Distribution and Its Stochastic Representation;European Journal of Pure and Applied Mathematics [Internet],2009

2. Wen X , Xu P , Zeng X , Liu J , Du C , Zeng X , et al. Development of [177Lu]Lu-LNC1003 for radioligand therapy of prostate cancer with a moderate level of PSMA expression. European Journal of Nuclear Medicine and Molecular Imaging 2023 50:9 [Internet]. 2023-04-25; 50(9). Available from: https://link.springer.com/article/10.1007/s00259-023-06229-w.

3. Galler M , Chibolela C , Rogasch JMM , Huang K , Siefert J , Schatka I , et al. Dosimetric analysis of a compartmental model for radioligand uptake in tumor lesions. Biomedical Physics & Engineering Express [Internet]. 2023-07-19; 9(5). Available from: https://iopscience.iop.org/article/10.1088/2057-1976/ace44a.

4. Yang T , Peng L , Qiu J , He X , Zhang D , Wu R , et al. A radiohybrid theranostics ligand labeled with fluorine-18 and lutetium-177 for fibroblast activation protein-targeted imaging and radionuclide therapy. European Journal of Nuclear Medicine and Molecular Imaging 2023 50:8 [Internet]. 2023-03-03; 50(8). Available from: https://link.springer.com/article/10.1007/s00259-023-06169-5.

5. Millul J , Bassi G , Mock J , Elsayed A , Pellegrino C , Zana A , et al. An ultra-high-affinity small organic ligand of fibroblast activation protein for tumor-targeting applications. Proc Natl Acad Sci U S A [Internet]. 2021 Apr 20 PMC8072232]; 118(16). Available from: https://pubmed.ncbi.nlm.nih.gov/33850024/.