Abstract
SUMMARYBalanced activity of canonical direct D1 and indirect D2 basal ganglia pathways is considered a core requirement for normal movement, and their imbalance is an etiologic factor in movement and neuropsychiatric disorders. We present evidence for a conceptually equivalent pair of direct-D1 and indirect-D2 pathways that arise from striatal projection neurons (SPNs) of the striosome compartment rather than from SPNs of the matrix, as do the canonical pathways. These S-D1 and S-D2 striosomal pathways target substantia nigra dopamine-containing neurons instead of basal ganglia motor output nuclei. They modulate movement oppositely to the modulation by the canonical pathways: S-D1 is inhibitory and S-D2 is excitatory. The S-D1 and S-D2 circuits likely influence motivation for learning and action, complementing and reorienting canonical pathway modulation. A major conceptual reformulation of the classic direct-indirect pathway model of basal ganglia function is needed, as well as reconsideration of the effects of D2-targeting therapeutic drugs.HIGHLIGHTSDirect S-D1 and Indirect S-D2 striosomal pathways target SNpc dopamine cellsThe S-D2 indirect pathway targets a distinct central external pallidal zone (cGPe)Stimulation of S-D2 increases, of S-D1 decreases, striatal dopamine and movementS-D1 SPNs activity brackets task, inverse to a mid-task peak of dopamine release
Publisher
Cold Spring Harbor Laboratory
Cited by
1 articles.
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