Psychological Resilience as a Mediator Between Depression and Quality of Life in Relapsing-Remitting Multiple Sclerosis Patients

Abstract

AbstractDepression represents a significant and prevalent challenge among individuals with multiple sclerosis (MS) substantially impacting their quality of life (QoL). This study explores the mediating role of psychological resilience in the relationship between depression and QoL in a sample of patients with multiple sclerosis (PwMS). This online cross-sectional study involves 179 Relapsing-Remitting Multiple Sclerosis (RRMS) patients. The PwMS completed three questionnaires: the Chicago Multiscale Depression Inventory, the Connor-Davidson Resilience Scale, and the Multiple Sclerosis Quality of Life (MSQOL-29). The results confirmed that higher levels of depression were associated with lower QoL in RRMS patients. However, the inclusion of psychological resilience as a mediator attenuated this direct effect, suggesting that resilience plays a crucial role in mitigating the negative impact of depression on QoL.