Measuring the response to visually presented faces in the human lateral prefrontal cortex

Abstract

AbstractNeuroimaging studies have identified multiple face-selective areas. In the current study we compared the functional response of the face area in the lateral prefrontal cortex to that of other face-selective areas. In Experiment 1 participants (N=32) were scanned viewing videos containing faces, bodies, scenes, objects, and scrambled objects. We identified a face-selective area in the right inferior frontal gyrus (rIFG). In Experiment 2 participants (N=24) viewed the videos or static images. Results showed that the rIFG, posterior superior temporal sulcus (pSTS) and occipital face area (OFA) exhibited a greater response to moving than static faces. In Experiment 3 participants (N=18) viewed face videos presented in the contralateral and ipsilateral visual fields. Results showed that the face areas in the IFG and pSTS responded equally to faces in both visual fields, while the OFA and fusiform face area (FFA) showed a contralateral bias. These experiments suggest two conclusions; firstly, in all three experiments the face area in the IFG was not as reliably identified as face areas in the occipitotemporal cortex. Secondly, the similarity of the response patterns in the IFG and pSTS face areas suggests that the areas are functionally connected, a conclusion consistent with neuroanatomical and functional connectivity evidence.