Abstract
AbstractAmple evidence indicates a sex-related difference in severity of COVID-19, with less favorable outcomes observed in men. Genetic factors have been proposed as candidates to explain this difference. The polyQ polymorphism in the androgen receptor gene has been recently described as a genetic biomarker of COVID-19 severity. In this study, we analyzed this association in a large cohort of 1136 men classified into three groups according to their degree of COVID-19 severity, finding a similar distribution of polyQ alleles among severity groups. Therefore, our results do not support the role of this polymorphism as a biomarker of COVID-19 severity.
Publisher
Cold Spring Harbor Laboratory
Reference19 articles.
1. The Physiological Mechanisms of the Sex-Based Difference in Outcomes of COVID19 Infection;Front Physiol [Internet],2021
2. Sex differences in COVID-19: candidate pathways, genetics of ACE2, and sex hormones;Am J Physiol Circ Physiol [Internet],2021
3. Zhang Q , Bastard P , Liu Z , Le Pen J , Moncada-Velez M , Chen J , et al. Inborn errors of type I IFN immunity in patients with life-threatening COVID-19. Science [Internet]. 2020;370(6515). Available from: http://www.ncbi.nlm.nih.gov/pubmed/32972995
4. Shorter androgen receptor polyQ alleles protect against life-threatening COVID-19 disease in European males;EBioMedicine [Internet],2021
5. Evidence for a repressive function of the long polyglutamine tract in the human androgen receptor: possible pathogenetic relevance for the (CAG)n-expanded neuronopathies;Hum Mol Genet [Internet],1995
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